About the Bonni Lab

The chief goal of research in the Bonni laboratory is to identify the principles and mechanisms that govern the assembly and function of neural circuits in the mammalian brain and to determine how these mechanisms are deregulated in neurological diseases including intellectual disability and autism spectrum disorders.

Dr. Bonni has discovered fundamental transcriptional, epigenetic, and ubiquitin-signaling networks that control distinct aspects of neuronal connectivity in the mammalian brain. The Bonni laboratory deploys a diverse set of tools and approaches from biochemistry, molecular biology, genetics, imaging and electrophysiology to the study of circuit assembly and function in the mouse and rat cerebellum.

Dr. Bonni will continue to advance the field of cerebellar circuit assembly and function including using new tools of in vivo imaging and optogenetics. In addition, Dr. Bonni is launching a new line of inquiry in the laboratory aimed at elucidating the neurobiological basis of autism spectrum disorders based on the hypothesis that deregulation of cerebellar circuit assembly and function contributes to the pathogenesis of these disorders. Ultimately, these studies will lay the foundation for the development of new therapeutic approaches in the treatment of autism.